Corneal endothelial cell measurements in megalocornea.

A pedigree of megalocornea manifested many of the characteristic features as well as some less common features of the disorder. Endothelial specular microscopy of affected patients disclosed normal endothelial cell densities and morphologic characteristics and increased total endothelial cell populations, suggesting a process of total corneal hyperplasia. In contrast, unpublished data indicate diminished densities in congenital glaucoma, a finding more consistent with corneal distention. We conclude that specular microscopy may be of value in differentiating the two disorders, although larger series are necessary for confirmation.

Intravitreal ciliary body neovascularization.

Two patients demonstrated an unusual conformation of intravitreal neovascularization, in which the abnormal blood vessels originated from the ciliary body. One of the patients had recurrent anterior chamber and vitreous hemorrhages. Both patients had undergone thermal ablative therapy of the ciliary body for the control of intraocular pressure. In one patient, fibrovascular tissue emanated directly from old cyclocryotherapy scars on the pars plana. Such neovascularization may represent a previously unrecognized complication of attempts at therapeutic destruction of the ciliary body.